A deductive system deriving ought from is cannot survive Hume's guillotine; Spencer's derivation of pleasure-maximizing duties from biological facts inherits this foundational logical gap.
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Hume's guillotine(the main argument referenced in the statement)
A famous logical problem named after philosopher David Hume showing that you can't logically jump from describing facts ('is') to prescribing duties ('ought')—the two types of statements operate differently.
Ought from is(the core philosophical problem being discussed)
The problem of trying to derive what people should do (moral duties) from facts about what actually exists or happens in the world.
Pleasure-maximizing duties(Spencer's specific moral theory)
The moral claim that people should try to increase happiness or pleasure, supposedly based on biological facts about how living things naturally seek pleasure.