Driesch's sea urchin blastomere experiments demonstrated totipotency across multiple cell divisions, not merely in earliest cleavage stages where 'reserve idioplasm' would plausibly remain intact.
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reserve idioplasm(Roux's auxiliary hypothesis to account for regenerative capacity in simpler organisms without abandoning mosaic determination theory)
A backup store of determinative material retained within each cell's nucleus, providing the capacity to reconstitute a whole organism if needed