In psychiatry, the relevant background population and conditions (developmental history, social context, gene-environment interactions) are not fixed across clinical contexts, so interventionist tests yield causal verdicts that fail to generalize.
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Generalize (in a scientific context)(as used in philosophy of science)
The ability to apply findings from one situation to other situations; if results don't generalize, they only work in the specific case you tested.
Interventionist tests(as used in philosophy of science and psychiatry)
Experiments where you deliberately change something (like a treatment or variable) to see what effect it has, rather than just observing what naturally happens.