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It is not the case that McGinn's closure argument conflates 'currently unexplained' with 'inexplicable in principle', committing a form of the argument from ignorance.
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Reasons For
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1.
McGinn's argument rests on evolutionary constraints on human cognition, not mere current ignorance—a structural, not temporary, limitation.
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2.
Analogies to past scientific progress don't establish we can overcome *fundamental* cognitive architecture limits, only previous empirical gaps.
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3.
The charge of 'argument from ignorance' mischaracterizes McGinn's claim about cognitive closure as a positive thesis about biological constraints.
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Reasons Against
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1.
History shows repeated cases where 'permanently inexplicable' phenomena later became explicable (vitalism, phlogiston, lightning).
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2.
Without independent criteria for 'inexplicable in principle,' McGinn merely asserts cognitive closure rather than proving it systematically.
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3.
Conflating epistemic limits (we can't know) with metaphysical limits (it can't be known) requires justification McGinn doesn't provide.
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