McGinn's closure thesis assumes the psychophysical link is a fixed, mind-independent fact rather than a framework-relative explanatory demand, which Dennett and eliminativists deny.

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Closure thesis(what McGinn proposes): McGinn's idea that the connection between mind and brain is a permanent mystery that human intelligence cannot solve, no matter how much we learn.
Dennett, Daniel(as the creator of the intentional-stance framework): A contemporary American philosopher who studies the mind and consciousness, known for arguing that we can understand how brains work by treating them as if they have beliefs and desires, even without knowing all the details of how neurons fire.
Framework-relative(philosophy of mathematics): Something that is true or makes sense only within a particular system or set of rules, rather than being true in all situations.
McGinn, Colin(the subject of the statement): A contemporary philosopher who argues that human minds may be fundamentally unable to understand how physical brains produce consciousness—like how a dog can't understand calculus.

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