Nozick's experience machine argument and related work establish that agents have agent-relative reasons tied to their particular situation that pure expected-utility maximization ignores.
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Pure expected-utility maximization(the limitation Nozick's argument identifies)
Using only the calculation of overall happiness or benefit to decide what's right, without considering anything else like personal relationships, your own projects, or special obligations.
agent-relative reasons(Both patient-centered and agent-centered deontologies are argued to generate agent-relative reasons.)
Reasons for action that are indexed to a particular agent and do not reduce to impersonal reasons about overall states of affairs.