Stigma constitutes a social burden distributed along lines of genetic variation, violating the difference principle by worsening the position of the least advantaged through no fault of their own.

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Genetic variation(as used in biology and philosophy): Natural differences in people's DNA and inherited traits that make individuals biologically different from one another.
No fault of their own(as used in ethics and responsibility discussions): Something that happens to a person because of circumstances beyond their control, not because of choices they made or mistakes they committed.
The Difference Principle(as a rule for judging fairness): Rawls's idea that inequality in a society is only fair if it makes the worst-off people better off than they would be under a more equal system.
least advantaged(Rawls's technical definition): Those with the least share of the primary goods of income and wealth, and powers and positions of office, who are also fully cooperating and active participants in society.

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