When feedback loops between biological, psychological, and social variables are constitutive of a disorder (as in network models of depression), surgical interventions on single nodes alter the system rather than test it.

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Biological, psychological, and social variables(the different types of elements that interact in depression): Factors related to your body (like brain chemistry), your mind (like your thoughts and feelings), and your environment (like relationships and stress), that can change and affect each other.
Feedback loops(describing how depression works in network models): When two or more things influence each other in a circular way—like how stress causes poor sleep, which increases stress, which causes worse sleep.
Network models (of depression)(the framework being discussed for how depression works): A way of understanding depression as a web of connected factors—thoughts, feelings, behaviors, and life circumstances—that all influence each other, rather than one single cause.
Nodes(in logic and model theory): Points or positions in a diagram or model that represent different possible situations or states of the world.

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