Moss and Keller's developmental systems theory shows that gene expression is inseparable from cellular and organismal environment, making 'genome-directed' therapy a category error.

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Category error(as used in logic and philosophy of language): A logical mistake where you apply a rule or concept to something it doesn't actually fit, like using a math formula on a poem.
Developmental systems theory(in biology and philosophy of science): A scientific approach that explains how living things develop by looking at how genes, environment, and other factors all work together rather than genes alone.
Gene expression(as a biological process): The process where the instructions stored in your genes actually get activated and put into action, creating proteins and traits—but this process depends heavily on what's happening in the cells and body around those genes.
Genome-directed therapy(as a therapeutic approach being critiqued): A medical treatment approach based on the idea that fixing genes alone will fix diseases, treating the genome (all your genetic material) as the primary control system.

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