The distinction between targeting 'the genome' and 'the organism' collapses when genomic interventions necessarily occur within and through the physiological context of a living body.

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Distinction collapses(the philosophical claim being made about Van Cleve's two categories): When two things that were thought to be different turn out to be the same thing, or no longer meaningfully different.
Necessarily: "Necessarily" means something must be true in all possible situations—it's not just true right now, but couldn't be false under any circumstances. For example, "2+2=4 necessarily" means there's no possible way 2+2 could equal anything other than 4. This contrasts with "contingently" true facts, like "it's raining today," which happen to be true but could have been false.
Organism(as what the argument is discussing): Any living thing, like a plant, animal, or human being—something that's alive and can grow, reproduce, and respond to its environment.
genome(Contrasted with the view of the genome as an eternal or immortal substance.): A highly complex set of dynamic activities (a process) crucial in maintaining the structural and functional stability of the organism and, through reproduction, of the lineage.

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