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    Inverse View

    It is not the case that Technological fixes for disease are directed at the genome rather than at the organism.

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    Reasons For

    2 perspectives
    Reason for 1 of 2
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    • 1.Gene therapy and CRISPR interventions act on somatic or germline cells as embodied biological systems, not on abstract genomic information alone.
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    • 2.The distinction between targeting 'the genome' and 'the organism' collapses when genomic interventions necessarily occur within and through the physiological context of a living body.
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    • 3.Moss and Keller's developmental systems theory shows that gene expression is inseparable from cellular and organismal environment, making 'genome-directed' therapy a category error.
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    Reason for 2 of 2
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    • 1.The beanbag conception attributed to classical population genetics was explicitly rejected by Ernst Mayr and has not governed molecular medicine's actual practice.
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    • 2.Contemporary precision medicine explicitly integrates genomic, proteomic, environmental, and phenotypic data, targeting disease at multiple levels of biological organization simultaneously.
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    Reasons Against

    1 perspective
    Reason against
    ?
    • 1.The beanbag conception of the organism treats organisms as reducible to collections of genes.
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    • 2.The concept of genetic disease relocates the locus of disease from the organism to the genome.
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    • 3.When disease is located in the genome, interventions target the genome.
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